Functional Links Between A Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.

Aβ (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity modifiers identified the yeast homolog of phosphatidylinositol binding clathrin assembly protein (PICALM) and other endocytic factors connected to AD whose relationship to Aβ was previously unknown...

cohesion and cohesive devices in a contrastive analysis between ge and esp texts

the present study was an attempt to conduct a contrastive analysis between general english (ge) and english for specific purposes (esp) texts in terms of cohesion and cohesive devices. to this end, thirty texts from different esp and ge textbooks were randomly selected. then they were analyzed manually to find the frequency of cohesive devices. cohesive devices include reference, substitution, ...

Relationship Between Lipid Profile and Cardiovascular Risk Factors and Lumbar Degenerative Disease in Adult Surgical Candidates

Background and Aim: There is no research consensus on the relationship between lipid profiles, atherosclerosis risk factors, and lumbar disc degeneration. The present study examined the relationship between lipid profile and some risk factors of cardiovascular diseases and lumbar disc degeneration in patients undergoing surgery. Methods and Materials/Patients: The study was conducted on ...

a framework for identifying and prioritizing factors affecting customers’ online shopping behavior in iran

the purpose of this study is identifying effective factors which make customers shop online in iran and investigating the importance of discovered factors in online customers’ decision. in the identifying phase, to discover the factors affecting online shopping behavior of customers in iran, the derived reference model summarizing antecedents of online shopping proposed by change et al. was us...

SnapShot: Endocytic Trafficking